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Starting Amount
$
After
years
Dividend yield
%
Dividends reinvested
$
Acceleron Pharma Inc.
Traded as NASDAQ: XLRN
Industry Biotechnology
Founded 2003 (2003)
Headquarters Cambridge, Massachusetts, United States
Key people
  • Habib Dable (CEO)
  • Steve Ertel (COO)
  • Matt Sherman (CMO)
  • Kevin McLaughlin (CFO)
  • Francois Nader (Chairman)
Website acceleronpharma.com
Footnotes / references
Key People

Acceleron Pharma, Inc. is a public American "clinical stage biopharmaceutical company" based in Boston, Massachusetts with a broad focus on developing medicines that regulate the transforming growth factor beta (TGF-β) superfamily of proteins, which play fundamental roles in the growth and repair of cells and tissues such as red blood cells, muscle, bone, and blood vessels.

Acceleron has four drugs in clinical trials, and one in preclinical development.

The company was formed in June 2003 in Cambridge, Massachusetts as a Delaware corporation; the original name was Phoenix Pharma.

The founders were scientists Jasbir Seehra, Tom Maniatis, Mark Ptashne, Wylie Vale, and scientific advisor Joan Massague, and business people and investors John Knopf and Christoph Westphal of Polaris Venture Partners, who served as founding CEO. The company was founded to discover and develop drugs based on the scientific discoveries of the scientific founders in the field of growth factors and transforming growth factors in the fields of metabolic disorders like obesity, diabetes, osteoporosis, and muscle-wasting conditions.

The company began with a seed round from Polaris of $250,000 and then had a Series A venture capital investment of $25 million that it used to open its first laboratory in December 2003.

Glenn Batchelder was appointed president and CEO in June 2004.

It started its first clinical trial in June 2006; the product was ACE-011 (which eventually was named "sotatercept"), a protein therapeutic that was an activin type 2 receptor antagonist intended to treat bone loss. ACE-011 was a chimeric protein, created by fusing the binding portion of the activin type 2 receptor to part of an antibody; the resulting protein binds to activin and prevents it from acting.

Knopf took over as CEO in 2007. He became known for showing pictures of a Belgian Blue cow to potential inventors, as a way of illustrating the company's products' potential to develop muscle.

In 2008 Acceleron and Celgene started a partnership to jointly develop and market ACE-011 in which Celgene paid Acceleron $50 million up front and bought $5 million of Acceleron stock, and agreed to buy $7 million more in stock if Acceleron went public, and agreed to pay up to $510 million in milestones. In a separate deal done at the same time, Celgene acquired an option to license three products in Acceleron's pipeline directed to cancer and cancer-related bone loss.

In 2011 Acceleron extended its their partnership with Celgene to include ACE-536, a development candidate for anemia; Celgene paid $25 million upfront, with potential downstream payments of $217 million in milestones and royalties over 10%.

The company held its initial public offering in September 2013. At that time, the company had three protein therapeutic candidates being studied in 12 Phase 2 clinical trials, including sotatercept and luspatercept (ACE-536) which promoted red blood cell production and were being tested as potential treatments for anemia in people with thalassemia and myelodysplastic syndromes (MDS); its other candidate was dalantercept (ACE-041), an angiogenesis inhibitor as a potential cancer drug.

In September 2016 Knopf retired and the company hired Habib Dable as CEO; at that time the company's lead product luspatercept was in Phase III testing for MDS and beta-thalassemia.

Investment goal date:
Dividends reinvested
Acceleron Pharma Inc. XLRN report Q3 2017
Period
Date
Adjusted Actuals EPS
GAAP EPS
Q1 2018
2018-05-07
--
--
Q4 2017
2018-02-28
--
--
Q4 2017
2018-02-27
--
--
Q3 2017
2017-11-07
--
--
Q3 2017
2017-11-07
-0.6500
0.0000
Q2 2017
2017-08-03
-0.7700
-0.7700
Q1 2017
2017-05-08
-0.6600
-0.6600
Q4 2016
2017-03-01
-0.5100
-0.5100
Q3 2016
2016-11-03
-0.5500
-0.5500
Q2 2016
2016-08-04
-0.5900
-0.5900
Q1 2016
2016-05-05
0.1300
0.1300
Q4 2015
2016-02-25
-0.8100
-0.8100
Q3 2015
2015-11-04
-0.3600
-0.3600
There is presents forecasts or rating agencies and recommendation for investors about this ticker
Funds
Fund Name
Ticker shares
BLACKROCK ADVISORS LLC
889177
BlackRock Fund Advisors
1347553
BlackRock Inc.
3674593
BlackRock Institutional Trust Company, N.A.
771977
EAGLE ASSET MANAGEMENT INC
1178959
FMR LLC
4838087
Hillhouse Capital Management, Ltd.
700000
Novo A/S
1553937
PERCEPTIVE ADVISORS LLC
663857
Polar Capital LLP
750000
Polaris Venture Management Co IV LLC
1480060
PRICE T ROWE ASSOCIATES INC /MD/
3903525
STATE STREET CORP
1034625
Vanguard Group, Inc
1912335
WESTFIELD CAPITAL MANAGEMENT CO LP
1147919
Major Shareholders
Name Relationship
Total Shares
Holding stocks